In 1996, Heche landed her first substantial role as a college student contemplating an abortion in a segment of the made-for-HBO anthology film If These Walls Could Talk, co-starring Cher and Demi Moore.

Also in the year, she appeared opposite Catherine Keener portraying childhood best friends in the independent film Walking and Talking.

Following a dual role in the daytime soap opera Another World (1987–91), she came to mainstream prominence in the late 1990s with the films Donnie Brasco (1997), Volcano (1997), Six Days, Seven Nights (1998), and Return to Paradise (1998).

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Although Heche was cast in a second starring role shortly thereafter as Vince Vaughn's love interest in the acclaimed drama Return to Paradise (1998), she felt that the romance with De Generes destroyed her prospects as a leading woman.

On her appearance in the dramatic thriller Return to Paradise, a writer for The New York Times remarked, "[...] as Ms.

While critical response towards the film was mixed, it grossed US$122 million at the international box office.

She portrayed the minor role of a backwoods loner in the slasher thriller sleeper hit I Know What You Did Last Summer, starring Jennifer Love Hewitt, Sarah Michelle Gellar, Ryan Phillippe, and Freddie Prinze, Jr..

'Hey Tay Tay, I've got a question for you,' she pretends to ask the star in a phone call. Scarlett Kardashian, Cowboy Ellen and Twerking Ellen - whom she dubs her favourite - were other versions stood in the line up.

; born May 25, 1969) is an American actress, director, and screenwriter.Heche's formidable Beth Eastern does her best to manipulate the other characters on [co-star Joaquin Phoenix's character] behalf, Return to Paradise takes on the abstract weightiness of an ethical debate rather than the visceral urgency of a thriller".Heche starred in Gus Van Sant's Psycho (1998), a remake of the 1960 film directed by Alfred Hitchcock.The limited-release film garnered favorable reviews from critics and is number 47 on Entertainment Weekly By the late 1990s, Heche continued to find recognition and commercial success as she took on supporting roles in three other 1997 high-profile film releases—Volcano, I Know What You Did Last Summer, and Wag the Dog.The disaster film Volcano, about the formation of a volcano in Los Angeles, had her star with Tommy Lee Jones and Gaby Hoffmann, playing a seismologist.Premiering September 25, 2017, Anne is now the series lead in the new 2017-18 NBC military drama The Brave.