Callie Torres and Derek Shepherd This friendship was based two things: work and Mark Sloan.

Who can forget Callie and Derek flanking Mark’s bedside as he lay dying? Afterward, it was as if they felt they owed it to Mark to keep up their relationship.

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I know he’s the president and all, but what would Mark think? April Kepner and Arizona Robbins A friendship that’s born while inebriated in a supply closet is a friendship that lasts.

Arguably the two perkiest docs at Grey Sloan, April and Arizona’s bond made sense and seemed easy.

It’s true, Alex had never really gelled with the group (he and George disliked each other to the very end), but the five did have each other’s back as a team.

They stuck together after the LVAD wire cut heard ‘round the world. They helped each other through hookups and true loves and surgical losses.

Sometimes they treated each other horribly, sometimes not.

But that time together as interns bonded them for life. Jackson Avery and Meredith Grey It’s surprising these two aren’t closer.

In fact, when you start to look at as a whole, you’ll quickly realize it’s rife with memorable friends — and, yes, a lot of pretty terrible ones.

Ahead of the show’s mid-season premiere, Vulture ranked all of the friendships forged in the halls of Grey Sloan, from worst to best. Andrew De Luca (Giacomo Gianniotti) and Jo Wilson (Camilla Luddington)Poor, sweet, dumb De Luca. Teddy Altman (Kim Raver) and Owen Hunt (Kevin Mc Kidd)Should Teddy and Owen even be on this list?

Keeping them as friends worked well for both parties: Riggs had an easy ally when he arrived in hostile territory at Grey Sloan, and April had someone who really understood what she went through. Cristina Yang and George O’Malley It never felt like Cristina respected George all that much, but they did share a lovely, tear-jerking moment when she welcomed him to the dead dad’s club. Their will-they, won’t-they friendship arc is one of the most compelling of the 13th season.

Riggs has since branched out, but we should get back to this relationship. I, for one, am counting down the days until they take each other in their big, burly arms and hug it out.

Also, being able to make Penny the least bit tolerable says a lot about this group’s chemistry. Teddy Altman and Arizona Robbins (Jessica Capshaw)This was great because Arizona saw Sad Teddy pining away for Owen and forced her to be friends.