Celexa (Citalopram) licensed indications: In January 2003, Prozac (fluoxetine) was approved by the FDA for the treatment of depression and OCD in children and adolescents who are 7 to 17 years of age.Zoloft (Sertraline) licensed indications: Clinical trials comparing one SSRI with another indicate that drugs in this class are equally efficacious.

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Lexapro is manufactured by Forest Pharmaceuticals, Inc. Neurotransmitters carry signals from one nerve cell to another.

Research suggests that abnormalities in neurotransmitter activity can affect mood and behavior.

Nausea The most common side effect associated with use of SSRIs is nausea.

Paroxetine and sertraline have been associated with slightly more cases of nausea.

The SSRIs are reported to cause sexual dysfunction in the following descending order of frequency: citalopram 72.7%; paroxetine 70.7%; sertraline 62.9%; fluvoxamine 62.3%; fluoxetine 57.7%.

Weight gain Weight gain is another troubling side effect. Paroxetine, fluoxetine, citalopram and sertraline have been shown to increase body weight after 612 months of therapy.

In due course, the levels of natural serotonin will rise again, and in some instances the SSRI can be reduced and withdrawn.

SSRI antidepressants are at least 10-fold more selective for serotonin reuptake inhibition than for norepinephrine reuptake.

The goal in such development is to produce agents that are more efficacious, safer and better tolerated than older medications.