In 2005, she appeared in the series Ihlamurlar Altında, directed by Aydın Bulut, and played Aysun in the film Babam ve Oğlum, directed by Çağan Irmak.Büyüküstün played a teacher in the 2006 movie Sınav (The Exam), where she had the opportunity to act alongside Jean-Claude Van Damme.After this rumours, Cesur ve Güzel (The Bold and the Beautiful) was announced, the new series of Tuba Büyüküstün, may be the greatest, because this time her partner is Kıvanç Tatlıtuğ – like the prince and the princess!

Her next series role was Zarife on Çemberimde Gül Oya, directed by Çağan Irmak, broadcast on Channel D in 2004.

That same year, she portrayed the title character in the television movie Gülizar.

Asi was a great drama about two families who has friend & foe situations for three generations.

At last, the beautiful Tuba Büyüküstün as Asi and handsome Murat Yıldırım as Demir fall in love while their families see each other as enemies.

She graduated in 2004 and started to take roles on small commercials, in the same year, she started to act in uba Büyüküstün’s beauty excited the attention of the audience immediately.

After the discovery of Tuba Büyüküstün’s beauty and talent, she started her first leading role in “Asi (Rebel)” tv series.

Their relationship was serious and the couple decided to get married in 2011.

Onur Saylak and Tuba Büyüküstün had their twin girls in .

In the fall of 2016, rumours started to spread “Tuba Büyüküstün and Onur Saylak will be divorced! The couple was silent against the claims for sometime.

It is said that the reason was about playing in new tv series and growing the kids.

Following this, she acted with Cansel Elçin in the series Gönülçelen.